Let the Treatment Begin!

Sunday we bid goodbye to Madeleine and Andreas -- they were such a godsend! - and took the train to Nurnberg, where we stayed for a couple of nights in the "Altstadt", the medieval part of the town that was painstakingly rebuilt after being bombed extensively during WWII. Here Liz and I discussed our strategy going forward (we liked Thaller a lot, but his treatment program is much more expensive!), and geared up for returning to Markt Berolzheim. By Tuesday morning we had acquired a cheap rental car (with a TomTom navigating device, a must for going to small towns!) and drove down to begin treatment.

Dr. Thaller gave us a warm welcome again, and gave me a "focus diagnostic" that led him to prescribe various homeopathic remedies for general detoxification. On the 2nd morning, I began the fever therapy -- 1 hour after the injection, I was shivering with chills, then in another 20 minutes I had a 103 - 104 degree fever (up to 38.9 Celsius) -- whew, that put me through the wringer very quickly! I spent all afternoon recovering from that. Fortunately I met two other patients with their helpers here who were all English-speakers -- they had all come over on the recommendation of Ralph Moss from the Moss report; this was really reaffirming that we were not alone in our strange quest to come to this farm town in Bavaria!

Thursday we spent the day driving cross-country to a very nice hospital clinic in the Black Forest . We stopped for lunch at a great café in Nordlingen, and enjoyed the scenery as we approached the "Black Forest" -- we are in a town, Donaueschingen, where the Danube River begins, and it is extremely beautiful. The windows to the hospital room are open all night, there is no TV in the room, and both my hospital room and Liz's family room are 30 Euros a night -- which seems incredibly low! Here a colleague of Dr. Thaller's, Dr Geiger, will insert two ports in my upper chest directly underneath the skin. Each will have a catheter in it that will guide either a virus or cancer vaccine injection directly to the neighborhood of the tumor . The idea is not to have the injection diluted by having to go through the entire bloodstream first; it will instead target the exact area of the tumor. The devices themselves won't be visible from the outside -- they will just be bumps in the skin, but injections can be made directly into their nylon core without any pain. Dr. Geiger seems very adept and intelligent, so I am looking forward to going off to the operation in a few minutes here!

(just back from the operation, everything went great. I came out of the anesthesia in a snap, and the doctor said the operation went very quickly. This afternoon there is a HUGE double rainbow outside the window -- very auspicious!)

Comparing Clinics in Germany

Here's a brief update on our adventures here in Germany. Everything is going well, my treatment has begun in earnest, and everyone here has been incredible!

That's the short version -- here's a little bit more detail. Liz and I arrived in Frankfurt and were met by one of our old friends Andreas at the airport -- he and his wife Madeleine and their two kids were vacationing in Germany when we came over, so they diverted their trip to help us out! Andreas drove us through heavy rain to the Hufeland Clinic in Bad Mergentheim on Thursday, where we had a good interview with Dr. Demuth. It was great having Liz and Andreas there with me -- we made a great team, and asked all the right questions! (and Andreas also provided some key translation help). The clinic itself was very professional-looking, and was surrounded by other clinics in an upscale spa town. Dr. Demuth was very professional, and his first recommendation was a conventional palliative treatment for bone strengthening (an IV drip of Zometa), which I can get in the US under my insurance. His clinic's treatments sounding interesting, and were a good integration of body and mind (psychological counseling as well as good alternative therapies), but all of us thought that the clinic was kind of "cancer lite" -- there was nothing specific in what Dr. Demuth said that would apply to my bone metastases, which is the most critical part of the cancer currently, and the most important to do something for.

We spent a great evening that night with Andreas and Madeleine and their kids Ava and Otto, at Andreas' brother's house in Heilbronn. (The brother is on vacation elsewhere, so we had the entire house to ourselves -- very nice!) The next morning we started the second round of interviewing, with Andreas driving us through the rain (again!) to visit the PraxisKlinik Arno Thaller in Markt Berolzheim. This is a tiny Bavarian farm town (the clinic is right next to a cow barn!) and the whole experience was much different than the previous day in Bad Mergentheim. Dr. Thaller operates the clinic out of his large house, and the whole place is filled with wood carvings, publications, a big piano and has a very homey feel. Dr. Thaller himself was large and gregarious, and we had a good conversation with him. He described his particular ideas for my treatment regimen, and it was specifically oriented toward attacking my bone metastases. He showed us pictures and diagrams of a very similar patient with advanced prostate cancer whom he had helped immensely -- the difference between the "before" and "after" bone scans of this patient was dramatic.

Dr. Thaller's treatment is a 4-step process that's focused on helping the body's immune system to attack the cancer. (I'm abridging here from his paper on the process, which you can read here)

• fever therapy (using Coley's Toxins) -- this injection induces a fever, which harms cancer cells much more than normal cells

• local hyperthermia -- this is a heat-generating machine that focuses heat on the tumor -- it's used at the peak of the fever induced from step 1 so that there's an additive effect on the cancer

• virus therapy (using Newcastle Disease Virus) -- this is a virus that's specifically bred on prostate cancer cells, and preferentially targets those cancer cells for destruction. The idea is that the virus gets in and destroys as many cancer cells as possible before the virus itself is destroyed by the immune system (the virus is completely harmless to normal cells). The virus also performs a secondary function of "marking" with an antigen many more cancer cells than it kills -- this primes them for the final step:

• cancer vaccine (or dendritic cell therapy) -- this step makes a vaccine from my own dendritic cells, and injects it back into my body to "wake up" my T-cells to start attacking and killing the cancer cells. American drug companies are doing final Phase III trials on some similar vaccines that are based on a generic prostate cancer cell; the results so far have been fair-to-middling. The advantages of Dr. Thaller's approach are that 1) the vaccine is made from my own dendritic cells, so it is individualized; and 2) the cancer cells have been previously "marked" by the Newcastle Disease Virus, so that they will be more readily attacked by the T-cells once the vaccine is injected.

During our interview, Dr. Thaller explained these four steps to us, as well as other anecdotes -- such as the time that he smuggled some of his special version of Newcastle Disease Virus into a clinic in Jerusalem, evading the airport authorities -- it was a very engaging interview! Andreas asked him at the end of the interview what he expected the result to be, and he stated emphatically: "it is my intention to cure him!" Of course he gave us the caveat that he could guarantee no such thing, but we all liked his positive and experimental attitude toward the case -- it sounded much more proactive than what we had heard from Dr. Demuth at the Hufeland Clinic.

That night we returned to Heilbronn and had a wonderful meal with Madeleine and Andreas and the whole family at Volksgarten, a restaurant serving local dishes -- it was delicious! (Spatzle, yum!) The next day was Ava's 8th birthday so we had a birthday party for her, went grocery shopping, and had a nice hike up into the vineyards that are on all of the hills at the top of the town -- they were only a few blocks uphill from the house where we were staying. Saturday was finally a beautiful sunny day!